Endothelial Senescence and Chronic Fatigue Syndrome, a COVID-19 Based Hypothesis

Sfera, Adonis and Osorio, Carolina and Zapata Martín del Campo, Carlos M. and Pereida, Shaniah and Maurer, Steve and Maldonado, Jose Campo and Kozlakidis, Zisis (2021) Endothelial Senescence and Chronic Fatigue Syndrome, a COVID-19 Based Hypothesis. Frontiers in Cellular Neuroscience, 15. ISSN 1662-5102

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Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome is a serious illness of unknown etiology, characterized by debilitating exhaustion, memory impairment, pain and sleep abnormalities. Viral infections are believed to initiate the pathogenesis of this syndrome although the definite proof remains elusive. With the unfolding of COVID-19 pandemic, the interest in this condition has resurfaced as excessive tiredness, a major complaint of patients infected with the SARS-CoV-2 virus, often lingers for a long time, resulting in disability, and poor life quality. In a previous article, we hypothesized that COVID-19-upregulated angiotensin II triggered premature endothelial cell senescence, disrupting the intestinal and blood brain barriers. Here, we hypothesize further that post-viral sequelae, including myalgic encephalomyelitis/chronic fatigue syndrome, are promoted by the gut microbes or toxin translocation from the gastrointestinal tract into other tissues, including the brain. This model is supported by the SARS-CoV-2 interaction with host proteins and bacterial lipopolysaccharide. Conversely, targeting microbial translocation and cellular senescence may ameliorate the symptoms of this disabling illness.

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 15 Apr 2023 08:01
Last Modified: 20 Jul 2024 09:25
URI: http://journal.submissionpages.com/id/eprint/959

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