Retinal Organoids: Cultivation, Differentiation, and Transplantation

Li, Xuying and Zhang, Li and Tang, Fei and Wei, Xin (2021) Retinal Organoids: Cultivation, Differentiation, and Transplantation. Frontiers in Cellular Neuroscience, 15. ISSN 1662-5102

[thumbnail of pubmed-zip/versions/2/package-entries/fncel-15-638439-r1/fncel-15-638439.pdf] Text
pubmed-zip/versions/2/package-entries/fncel-15-638439-r1/fncel-15-638439.pdf - Published Version

Download (1MB)

Abstract

Retinal organoids (ROs), which are derived from stem cells, can automatically form three-dimensional laminar structures that include all cell types and the ultrastructure of the retina. Therefore, they are highly similar to the retinal structure in the human body. The development of organoids has been a great technological breakthrough in the fields of transplantation therapy and disease modeling. However, the translation of RO applications into medical practice still has various deficiencies at the current stage, including the long culture process, insufficient yield, and great heterogeneity among ROs produced under different conditions. Nevertheless, many technological breakthroughs have been made in transplanting ROs for treatment of diseases such as retinal degeneration. This review discusses recent advances in the development of ROs, improvements of the culture protocol, and the latest developments in RO replacement therapy techniques.

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 14 Apr 2023 08:19
Last Modified: 16 Sep 2024 10:06
URI: http://journal.submissionpages.com/id/eprint/956

Actions (login required)

View Item
View Item