Molecular Basis of Pathogenesis of Ectopic Fat Deposition in DM2 – An Overview

Prasad, A. S. V. (2019) Molecular Basis of Pathogenesis of Ectopic Fat Deposition in DM2 – An Overview. International Journal of Biochemistry Research & Review, 25 (4). pp. 1-10. ISSN 2231-086X

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Abstract

The presence of fat, beyond physiological limits, in organs, other than the adipose tissue, like the liver, the skeletal muscle, the heart and the pancreas etc is called ectopic fat. It causes specific organ dysfunction in the tissues concerned. The importance of the ectopic fat is that it is connected to peripheral tissue insulin resistance, obesity, metabolic syndrome etc. Though the molecular mechanisms underlying the specific organ dysfunctions are understood, still grey areas exists as to the source of the ectopic fat and how it finds it’s way to the specific sites of the target organs (intra- myocellular in skeletal muscle, hepatocyte cytoplasm of liver, epicardial surface and coronary arteries of heart etc.). The molecular mechanisms involving the actual ectopic deposition fat, are not clear. This article focuses on some of the grey areas in the pathogenesis of the ectopic fat deposition, besides reviewing briefly the facts already known in the literature about ectopic fat deposition.

Item Type: Article
Subjects: STM Open Press > Biological Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 01 Apr 2023 06:47
Last Modified: 24 May 2024 06:09
URI: http://journal.submissionpages.com/id/eprint/774

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