Lopez-Virgen, Veronica and Olivares-Moreno, Rafael and de Lafuente, Victor and Concha, Luis and Rojas-Piloni, Gerardo (2022) Different subtypes of motor cortex pyramidal tract neurons projects to red and pontine nuclei. Frontiers in Cellular Neuroscience, 16. ISSN 1662-5102
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Abstract
Introduction: Pyramidal tract neurons (PTNs) are fundamental elements for motor control. However, it is largely unknown if PTNs are segregated into different subtypes with distinct characteristics.
Methods: Using anatomical and electrophysiological tools, we analyzed in mice motor cortex PTNs projecting to red and pontine midbrain nuclei, which are important hubs connecting cerebral cortex and cerebellum playing a critical role in the regulation of movement.
Results: We reveal that the vast majority of M1 neurons projecting to the red and pontine nuclei constitutes different populations. Corticopontine neurons have higher conduction velocities and morphologically, a most homogeneous dendritic and spine distributions along cortical layers.
Discussion: The results indicate that cortical neurons projecting to the red and pontine nuclei constitute distinct anatomical and functional pathways which may contribute differently to sensorimotor integration.
Item Type: | Article |
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Subjects: | STM Open Press > Medical Science |
Depositing User: | Unnamed user with email support@stmopenpress.com |
Date Deposited: | 23 Mar 2023 06:41 |
Last Modified: | 04 Sep 2024 03:56 |
URI: | http://journal.submissionpages.com/id/eprint/717 |