Different subtypes of motor cortex pyramidal tract neurons projects to red and pontine nuclei

Lopez-Virgen, Veronica and Olivares-Moreno, Rafael and de Lafuente, Victor and Concha, Luis and Rojas-Piloni, Gerardo (2022) Different subtypes of motor cortex pyramidal tract neurons projects to red and pontine nuclei. Frontiers in Cellular Neuroscience, 16. ISSN 1662-5102

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Abstract

Introduction: Pyramidal tract neurons (PTNs) are fundamental elements for motor control. However, it is largely unknown if PTNs are segregated into different subtypes with distinct characteristics.

Methods: Using anatomical and electrophysiological tools, we analyzed in mice motor cortex PTNs projecting to red and pontine midbrain nuclei, which are important hubs connecting cerebral cortex and cerebellum playing a critical role in the regulation of movement.

Results: We reveal that the vast majority of M1 neurons projecting to the red and pontine nuclei constitutes different populations. Corticopontine neurons have higher conduction velocities and morphologically, a most homogeneous dendritic and spine distributions along cortical layers.

Discussion: The results indicate that cortical neurons projecting to the red and pontine nuclei constitute distinct anatomical and functional pathways which may contribute differently to sensorimotor integration.

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 23 Mar 2023 06:41
Last Modified: 04 Sep 2024 03:56
URI: http://journal.submissionpages.com/id/eprint/717

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