SURVIVAL ANALYSIS AND SPATIAL-FREQUENCY DISTRIBUTION OF EEG-INDICES IN RATS’ GLOBAL CEREBRAL ISCHEMIA

GANTSGORN, E. V. and KHLOPONIN, D. P. and MAKLYAKOV, Yu. S. (2017) SURVIVAL ANALYSIS AND SPATIAL-FREQUENCY DISTRIBUTION OF EEG-INDICES IN RATS’ GLOBAL CEREBRAL ISCHEMIA. Kubanskij nauchnyj medicinskij vestnik, 1 (2). pp. 43-49. ISSN 1608-6228

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Abstract

Research goal was an evaluation of survival and electroencephalographic (EEG) indices in rats with experimental cerebral ischaemia (ECI) during the preventive application of cerebroprotective drugs: nootropics (piracetam (300 mg/ kg/day) and vinpocetine (5 mg/kg/day)) in combination with melaxen (0,25 mg/kg/day). Global CI was modelled by left and right common carotid arteries (CCA) ligation. It was founded that preventive combined application of vinpocetine and melaxen reduced significantly (about 2.5 times (р≤0,01)) rats lethality and influence of circulatory ischemia adverse effects on survived experimental animals brain functional state. Only in the rats receiving these drugs were registered frequency ranges close to the baseline, specifically, theta (θ)-rhythm was dominated over delta (Δ)-activity, indicating waking state of the rats’ brain. The results obtained can be used in clinical practice for prevention and treatment of ischemic brain diseases.

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 14 Mar 2023 11:10
Last Modified: 07 Sep 2024 10:14
URI: http://journal.submissionpages.com/id/eprint/656

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