DIAGNOSTIC POSSIBILITIES OF RESEARCHING THE STATE OF NEUROMUSCULAR TRANSMISSION IN PATIENTS WITH MYASTHENIA AND MYASTHENIC SINDROMES

Aim. To study and analyse diagnostic meaningfulness of the different electromyographic methods applied for the exposure of violations of neuromuscular transmission transmission.

Materials and methods. There are many methods of the researching of the condition of neuro muscular transfer, each of them carries the certain diagnostic importance allowing to define character of a lesion of a neuro muscular synapse, to tap mechanisms of its development not only in clinically affected muscles, but also intact ones, and also at an early stage of a disease, at local forms of a myasthenia. The research of the condition of neuromuscular transmission was carried out with the use of the following electromyographic techniques: stimulation electroneuromyography (ENMG), the decrement test, the jitter-phenomenon, research of density of a single muscle fiber.

Results. The result of the analysis of electromiographic diagnostic opportunities of researching the condition of neuro muscle fiber development is the developing of the clinic-instrumental algorithm of inspection of patients with a myasthenia.

Conclusion. The different neurophysiological methods of study of the state of neuromuscular transmission carry certain diagnostic meaningfulness. Advantages of separate electromyographic methods are shown: research of initial amplitude of M-answer, decrement-test, джиттер-phenomenon. The indexes of ENMG-tests are analysed in detail-tests, and also their change at violation of neuromuscular transmission for patients with myasthenia gravis and myasthenic syndromes.