The Potential for microRNA Therapeutics and Clinical Research

Hanna, Johora and Hossain, Gazi S. and Kocerha, Jannet (2019) The Potential for microRNA Therapeutics and Clinical Research. Frontiers in Genetics, 10. ISSN 1664-8021

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Abstract

As FDA-approved small RNA drugs start to enter clinical medicine, ongoing studies for the microRNA (miRNA) class of small RNAs expand its preclinical and clinical research applications. A growing number of reports suggest a significant utility of miRNAs as biomarkers for pathogenic conditions, modulators of drug resistance, and/or as drugs for medical intervention in almost all human health conditions. The pleiotropic nature of this class of nonprotein-coding RNAs makes them particularly attractive drug targets for diseases with a multifactorial origin and no current effective treatments. As candidate miRNAs begin to proceed toward initiation and completion of potential phase 3 and 4 trials in the future, the landscape of both diagnostic and interventional medicine will arguably continue to evolve. In this mini-review, we discuss miRNA drug discovery development and their current status in clinical trials.

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 06 Feb 2023 07:01
Last Modified: 09 Jul 2024 07:30
URI: http://journal.submissionpages.com/id/eprint/282

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