Use of Postbiotics as an Immunomodulatory of the Immune Response against Brucellosis in Nellore Calves Immunized with S 19 Vaccine

Background: Brucellosis is an important public health disease and a great problem in the cattle production.

Objectives: The aim of this study was to evaluate the immunomodulatory efficiency of a commercial postbiotic in Nellore calves immunized with the Brucella abortus S19 vaccine.

Methods: We used 40 calves negative for Brucella spp. organizated into four treatments during 15 days: InRum (Ingulbal Ruminant®); InPro (Ingulbal Protein®); RumPro (Ingulbal Ruminant® and Ingulbal Protein®); and Cont: control. Collections of whole blood and serum samples were performed at the beginning of the administration of postbiotic and at 15, 45, 75 and 105 days after start the experiment. At 15 days, all animals received the mandatory vaccine S19. In order to assess immunological parameters, the means of total white cells counts, total lymphocytes, monocytes and neutrophils, and total IgG antibodies were determined.

Results: It found a significative increase (P<0.05) of white cells counts and serum IgG levels in the three treatment groups throughout the experiment. Additionally, we observe a tendency not significative in a greater number of lymphocytes, monocytes and neutrophils counts in the treat calves.

Conclusion: Our results suggest that the supplementation with postbiotic is a promising alternative to modulate both the cellular and humoral immune response of S19 vaccine against bovine brucellosis.