The Role of Semaphorin 3A in Bone Remodeling

Li, Zhenxia and Hao, Jin and Duan, Xin and Wu, Nan and Zhou, Zongke and Yang, Fan and Li, Juan and Zhao, Zhihe and Huang, Shishu (2017) The Role of Semaphorin 3A in Bone Remodeling. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102

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Abstract

Bone remodeling occurs at the bone surface throughout adult life and associates bony quantity and quality. This process is a balance between the osteoblastic bone formation and osteoclastic bone resorption, which cross-talks together. Semaphorin 3A is a membrane-associated secreted protein and regarded as a diffusible axonal chemorepellent, which has been identified in the involvement of bone resorption and formation synchronously. However, the role of Semaphorin 3A in bone homeostasis and diseases remains elusive, in particular the association to osteoblasts and osteoclasts. In this review article, we summarize recent progress of Semaphorin 3A in the bone mass, homeostasis, and diseases and discuss the novel application of nerve-based bone regeneration. This will facilitate the understanding of Semaphorin 3A in skeletal biology and shed new light on the modulation and potential treatment in the bone disorders.

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 27 Jun 2023 06:06
Last Modified: 21 Sep 2024 04:07
URI: http://journal.submissionpages.com/id/eprint/1685

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