In vitro Antibacterial Activity of n-Hexane Fraction of Methanolic Extract of Alstonia scholaris L. R.Br. Stem Bark against Some Multidrug Resistant Human Pathogenic Bacteria

Mukherjee, Souryadeep and Dey, Abhijit and Das, Trisha (2011) In vitro Antibacterial Activity of n-Hexane Fraction of Methanolic Extract of Alstonia scholaris L. R.Br. Stem Bark against Some Multidrug Resistant Human Pathogenic Bacteria. European Journal of Medicinal Plants, 2 (1). pp. 1-10. ISSN 22310894

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Abstract

Plants are a source of wide range of bioactive molecules. Alstonia scholaris, a tree species of Apocynaceae family is being reported as a well known herbal remedy of various diseases. In the present investigation, n-hexane fraction of crude methanolic extract of Alstonia scholaris Linn. R.Br. stem bark was evaluated for antibacterial activity using four human pathogenic multi-drug resistance bacterial strains Enterobacteriaceae bacterium IK1_01, Shigella dysentery, Enterobacter cloacae and Serratia marcescens. Antibiotic susceptibility tests were also performed to evaluate the multi-drug resistance patterns of these strains. All the strains showed multi-drug resistance against several commercially available antibiotics. The n-hexane fraction showed significant inhibitory activities against all the strains by agar-diffusion assay. The n-hexane fraction of crude methanolic extract of stem of A. scholaris showed MICs of 5.5 mg/ml, 5 mg/ml, <5.5 mg/ml and 8 mg/ml, and induced a maximum of 85.7%, 95.6%, 89.3% and 94.4% growth inhibition against E. bacterium IK1_01, S. dysentery, E. cloacae and S. marcescens, respectively.

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 28 Jun 2023 04:43
Last Modified: 06 Jul 2024 07:03
URI: http://journal.submissionpages.com/id/eprint/1656

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