Are Biodegradable Third Generation Drug Eluting Stents the Answer to Instent Restenosis?

Amritphale, Amod and Amritphale, Nupur and Ahsan, Chowdhury H. (2014) Are Biodegradable Third Generation Drug Eluting Stents the Answer to Instent Restenosis? Cardiology and Angiology: An International Journal, 2 (1). pp. 15-40. ISSN 2347520X

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Abstract

The third generation biodegradable Drug Eluting Stent (DES) are being evaluated and being introduced in clinical practice. They have been DESigned to overcome limitations associated with durable polymer and a persistent metallic stent scaffold which could be related to late target lesion revascularization (TLR) and very late stent thrombosis (VLST). Although a recent pooled data analysis found that biodegradable polymer stents were superior for TLR and VLST compared with first generation Sirolimus Eluting Stent (SES), superiority has not been demonstrated against second generation Everolimus eluting stents (EES) and is yet to be conclusively proven in randomized trials. This paper reviews the key features, recent trial data, and future directions of the third generation of DES technology including stents with fully biodegradable scaffolds, stents with biodegradable polymer, and polymer free stents.

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 10 Jul 2023 05:17
Last Modified: 18 Oct 2024 04:19
URI: http://journal.submissionpages.com/id/eprint/1561

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