Sildenafil and Vinpocetine Promote Wound Healing in Diabetic Rats

Barakat, Waleed and Anwar, Hany and Fouad, Mona (2020) Sildenafil and Vinpocetine Promote Wound Healing in Diabetic Rats. Journal of Advanced Pharmacy Research, 5 (1). pp. 211-221. ISSN 2357-0539

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Abstract

Objectives: Many diabetic patients develop foot ulcer that might affect gait, quality of life and may lead to amputation. The present study was designed to investigate the possible effect of phosphodiesterase inhibitors (sildenafil 10 mg/kg/day and vinpocetine 5 mg/kg/day) on healing of experimentally-induced diabetic foot wound in comparison to glimepiride (0.5 mg/Kg/day). Methods: All treatments were started on day 15 after streptozotocin (STZ) injection and continued daily for 8 weeks. After 4 weeks of treatment, a wound of fixed size was induced in the dorsal surface of right foot and wound healing was followed throughout the study. Behavior tests (foot print and hot plate test) were performed every 2 weeks. At the end of the study, animals were euthanized, serum insulin, glucose, HbA1C, IL6 and adiponectin were quantified and H& E stained sections (from right foot) were investigated. Results: Diabetes delayed wound healing, elevated blood glucose, HbA1c, IL-6, reduced serum insulin and adiponectin. While, treatment with sildenafil, vinpocetine and glimepiride ameliorated most of these effects. Conclusions: In conclusion, phosphodiesterase inhibitors as sildenafil, and vinpocetine were effective in ameliorating some of the deleterious effects on diabetes on wound healing indicating that they could be used with other standard therapies for the management of diabetic foot ulcer (DFU).

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 12 Jun 2023 04:59
Last Modified: 26 Jul 2024 06:44
URI: http://journal.submissionpages.com/id/eprint/1506

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