Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity

El-Shanbaky, Hend and Abd El-Hameed, Rania and Mohamed, Mosad (2020) Synthesis of Heterocyclic and Non-heterocyclic Compounds Derived from Novel 2-Furanones and Evaluation of their Anti-viral Activity. Journal of Advanced Pharmacy Research. 0-0. ISSN 2357-0539

[thumbnail of APRH_Volume 5_Issue 1_Pages 202-210.pdf] Text
APRH_Volume 5_Issue 1_Pages 202-210.pdf - Published Version

Download (518kB)

Abstract

Objective: The aim of the present study is to synthesize novel 2-furanones due to their biological activities and also their ability to be converted to several biologically active heterocyclic and non-heterocyclic compounds. Methods: Two novel 2-furanone derivatives were synthesized and used to prepare fourteen heterocyclic and non-heterocyclic compounds. Structures of all the newly synthesized compounds were confirmed by elemental and spectral analysis including Mass, IR and 1H-NMR spectroscopy. Evaluation of antiviral activity of selected examples of the obtained compounds was performed using two gastroenteric viruses: adenovirus and rotavirus. Results: Two pyridazinone derivatives namely; 3-(3,4-Dichlorophenyl)-5-[(2-methoxypheny)l-methyl]-1H-pyridazin-6-one (7a) and 3-(3,4-Dichlorophenyl)-5-[(4-fluropheny)l-methyl]-1H-pyridazin-6-one (7b) showed high activities against rotavirus. Conclusions: Compounds 7a and 7b can be considered as promising anti-rotaviral agents needing further investigations and clinical studies.

Item Type: Article
Subjects: STM Open Press > Medical Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 12 Jun 2023 04:59
Last Modified: 04 Jun 2024 11:26
URI: http://journal.submissionpages.com/id/eprint/1505

Actions (login required)

View Item
View Item