The p53 Codon 72 Polymorphism in Moroccan Women and the Risk of Ovarian Cancer

The aim of this study was to examine the association of the p53 codon 72 polymorphism with ovarian carcinoma development in Moroccan women.

Samples from 44 women with ovarian cancer and 80 healthy controls, were used. p53 codon 72 polymorphism determination was performed by allele-specific PCR assay. The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes was 33/44 (75%), 10/44 (22.7%) and 1/44 (2.3%) in the cervical cancer group and 43/80 (53.8%), 27/80 (33.7%) and 10/80 (12.5%) in the control group. No significant association was found between polymorphism of p53 and risk of development of ovarian cancer among Moroccan women. Thus, the polymorphism of p53 codon 72 in exon 4 does not seem to play a role in the development of ovarian cancer among Moroccan women.