Discovery, Modification and Production of T4 Lysozyme for Industrial and Medical Uses

Alhazmi, Alaa and Stevenson, Johnathan Warren and Amartey, Samuel and Qin, Wensheng (2014) Discovery, Modification and Production of T4 Lysozyme for Industrial and Medical Uses. International Journal of Biology, 6 (4). pp. 45-63. ISSN 1916-9671

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Abstract

Lysozyme has attracted immense attention as an antimicrobial agent because of its ability to lyse the bacterial cell wall. It is found in a wide variety of body fluids and in cells of the innate immune system. Lysozyme can act as muramidase or as a Cationic Antimicrobial Peptide (CAMP). Lysozyme has many applications in the medical and industrial fields. Based on enzyme nomenclature, lysozyme is classified as a glycosylase under the group hydrolases. This manuscript covers a fundamental review of lysozyme in terms of discovery, history, functions and various sources and types of lysozyme. The biological and molecular structure is discussed as well as notable bioengineering and protein modifications. Furthermore, the mechanisms of resistance to lysozyme in microorganisms have also been discussed. Lastly, different methods that have been developed for detecting and measuring the activity of lysozyme are outlined. Although, a recombinant lysozyme has not yet been produced, several studies have attempted to generate a modified lysozyme either for large-scale production or that which is more suitable for industrialization purposes.

Item Type: Article
Subjects: STM Open Press > Biological Science
Depositing User: Unnamed user with email support@stmopenpress.com
Date Deposited: 23 May 2023 05:54
Last Modified: 13 Sep 2024 07:21
URI: http://journal.submissionpages.com/id/eprint/1326

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