Ultrastructure of Thyroid and Parathyroid Bodies in Case of Hypocalcemia and Hypercalcemia

Aims: To analyze ultrastructural transformations of parafollicular cells of thyroid body and main cells of Parathyroid body in case of experimental blood hypocalcemia and hypercalcemia.

Place and Duration of Study: Tashkent State Dental Institute, between April 2015 and October 2015.

Methodology and Study Design: White outbreed male rats with the mass of 130-140 g were split by 3 groups based on content of the free calcium ions in the blood serum: normal (benchmark, n=10); low (hypocalcemia, n=40); high (hypercalcemia, n=40). Experimental intraperitoneal administration of 2,5% ethylenediominotetraacetic acid and 10% Calcium gluconate during 1, 3, 6 and 10 days resulted in hypocalcemia and hypercalcemia consequently, in elevation and reducing the parathormone contained in the blood.

Results: In case of the normal content of the calcium ions in the blood, the main, oxyphilic, intermediate and cambial cells were identified. The main cells as the most numerous ones are characterized with oblong form and small size. The nucleus is large, located eccentrically, the nucleolem may be even, sulcated, with invagination, and nucleoplasm is rich with euchromatin.

Conclusion: Hypocalcemia after ethylenediominotetraacetic acid introduction in 1, 3, 6 and 10 days is activating B type cells. Hypercalcemia after calcium gluconate introduction in 1, 3, 6 and 10 days causes hy Parathyroid body po-function.